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Biomedical Sensors & Clinical Systems
Translating sensing technology into clinical and everyday healthcare use requires platforms that can diagnose, treat, and continuously monitor physiological signals across a wide range of biointerfaces. Our group addresses this need through three complementary approaches: fiber-integrated interfaces that embed diagnostic and therapeutic function directly within wearable textile materials; optoelectronic platforms that quantify colorimetric biosignals as wireless, reliable electronic outputs for wound and biofluid diagnostics; and implantable, multimodal biointegrated sensor systems that enable continuous physiological monitoring in clinical and wearable settings. Together, these platforms advance a comprehensive pipeline from passive diagnostic textiles to implantable clinical sensing tools for next-generation biomedical and healthcare applications.
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4-1. Fiber-Integrated Diagnostic and Therapeutic Interfaces
We have developed electrospun fiber-based platforms that embed diagnostic and therapeutic function directly within the fiber material, without relying on separate sensing circuitry [1,2,3]. By tailoring fiber composition and surface properties, these textiles combine diagnostic monitoring, wound protection, and antimicrobial activity within a single functional layer. The integration of nanotransfer printing further extends this platform to curved, microscale fiber surfaces, enabling diagnostic and antimicrobial functions to emerge from a shared fabrication process. These fiber-encoded interfaces pave the way for passive, reusable, and adhesive-free sensing and therapeutic solutions for wearable healthcare garments.
- [1] Ha, J.-H., Kim, J. Y., Kim, D., Ahn, J., Jeong, Y., Ko, J., Hwang, S., Jeon, S., Jung, Y., Gu, J., Han, H., Choi, J., Lee, G., Bok, M., Park, S. A., Cho, Y. S., Jeong, J.-H., and Park, I. (2023). Multifunctional Micro/Nanofiber Based-Dressing Patch with Healing, Protection, and Monitoring Capabilities for Advanced Wound Care. Advanced Materials Technologies, 2201765.
- [2] Ha, J.-H. et al., Jeong, J.-H., Park, I. (2023). Wearable Colorimetric Sweat pH Sensor-based Smart Textile for Health State Diagnosis. Materials Horizons.
- [3] Ha, J.-H. et al., Jeong, J.-H., Park, I. (2024). Nanotransfer Printing of Functional Nanomaterials on Electrospun Fibers for Wearable Healthcare Applications. Advanced Functional Materials, 2401404.
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Figure 1. Fiber-integrated diagnostic and therapeutic interfaces: (a) dual-layer dressing patch with healing, protection, and monitoring capabilities, schematic of curcumin-TPU composite electrospinning, heat-press attachment to clothing, and colorimetric sweat pH sensing for cystic fibrosis diagnosis (I. Park et al., Materials Horizons, 2023), (b) nanotransfer-printed electrospun TPU fibers applied to a wearable SERS healthcare sensor and a protective antibacterial medical garment (I. Park et al., Advanced Functional Materials, 2024).
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4-2. Optoelectronic Quantification of Colorimetric Biosignals
We have developed wireless, battery-free optoelectronic platforms that directly quantify biosignals without relying on photographic image capture, avoiding the sensitivity to ambient lighting and skin tone associated with conventional colorimetric readout [4,5,6]. By coupling functional dressings and microfluidic assays with dedicated optical readout modules, these systems convert physical and chemical changes at the sensor interface into wireless electronic outputs for real-time biomarker monitoring. This capability spans applications from wound diagnostics to multiplexed biofluid analysis, and is further situated within a broader perspective on optical sensing principles, materials, and power strategies for wearable photonic biosensors [7].
- [4] Cho, S., Ha, J.-H., Ahn, J., et al., Jeong, J.-H.* and Park, I.* (2024). Wireless, Battery-Free, Optoelectronic Diagnostic Sensor Integrated Colorimetric Dressing for Advanced Wound Care. Advanced Functional Materials, 2316196.
- [5] Song, R., Cho, S., Kim, G., et al., Park, I.* and Gao, W.* (2026). Wireless, Battery-Free Wearable Optoelectronic-Colorimetric Microfluidic Sensor for Multiplex Sweat Analysis. Device, 4, 101107.
- [6] Cho, S., Ha, J.-H., Moon, J., Ahn, J., et al., Jeong, J.-H., Gao, W. and Park, I.* (2026). Wireless, Battery-Free, Optoelectronic, Multi-Modal Sensor Integrated With Colorimetric Dressing for Diabetic Ulcer Management. Advanced Functional Materials, e32167.
- [7] Song, R., Cho, S., Khan, S., Park, I.* and Gao, W.* (2025). Lighting the Path to Precision Healthcare: Advances and Applications of Wearable Photonic Sensors. Advanced Materials, 2419161.
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Figure 2. Optoelectronic quantification of colorimetric biosignals: (a) wireless, battery-free optoelectronic-colorimetric microfluidic patch for multiplexed sweat analysis of uric acid, alcohol, and pH (I. Park, et al., Device, 2026); (b) dual-biomarker electrospun colorimetric dressing (C-PCL/TGP-PCL) with integrated optoelectronic quantification of pH and glucose for diabetic wound monitoring (I. Park et al., Advanced Functional Materials, 2026).
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4-3. Implantable, Multimodal Biointegrated Sensor Systems
We have developed implantable, battery-free, wireless sensing platforms capable of simultaneously capturing multiple physiological signals around an injured peripheral nerve, with sensor and circuit design enabling reliable decoupling of co-located signals. Validation in vivo in small animal models, including continuous monitoring through nerve injury, supports the feasibility of this approach and reflects a broader trend toward integrating multiple sensing modalities into implantable and clinical medical tools, as well as wearable devices more broadly for health monitoring [8,9,10].
- [8] Kim, S., Oh, Y. S., Lee, K., Kim, S., Maeng, W.-Y., Kim, K. S., Kim, G.-B., Cho, S., Han, H., Park, H., Wang, M., Avila, R., Xie, Z., Ko, K., Choi, J., Je, M., Lee, H., Lee, S., Koo, J.* and Park, I.* (2023). Battery-Free, Wireless, Cuff-Type, Multimodal Physical Sensor for Continuous Temperature and Strain Monitoring of Nerve. Small, 2206839.
- [9] Park, J., Seo, B., Jeong, Y. and Park, I.* (2024). A Review of Recent Advancements in Sensor-Integrated Medical Tools. Advanced Science, 2307427.
- [10] Brazaca, L. C., et al., Park, I., et al., Sempionatto, J.* and Oliveira Jr., O. N.* (under review). Advances and Challenges in Wearable Sensors for Health Monitoring. ACS Applied Materials & Interfaces, 18, 39567–39694.
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Figure 3. Implantable, multimodal biointegrated sensor systems:, (a) sensor-integrated medical tools across needles, catheters, robotic surgery instruments, and other clinical devices (I. Park et al., Advanced Science, 2024), (b) Advances and challenges in wearable sensors for health monitoring (I. Park et al., Acs ami) (c) battery-free, wireless, cuff-type multimodal sensor for continuous temperature and strain monitoring of nerve (I. Park et al., Small, 2023).
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